Test Code SBL Blastomyces Antibody by Immunodiffusion, Serum
Reporting NameBlastomyces Ab, Immunodiffusion, S
Detection of antibodies in patients having blastomycosis
Performing LaboratoryMayo Medical Laboratories in Rochester
Preferred: Serum gel
Acceptable: Red top
Specimen Volume: 0.5 mL
Forms: If not ordering electronically, complete, print, and send a Neurology Test Request Form-General (T732) with the specimen (http://www.mayomedicallaboratories.com/it-mmfiles/neurology-request-form.pdf)
Specimen Minimum Volume
Specimen Stability Information
|Serum||Refrigerated (preferred)||14 days|
Reject Due To
Mild OK; Gross reject
Mild OK; Gross reject
Day(s) and Time(s) Performed
Monday through Friday; 9:30 a.m.
CPT Code Information
LOINC Code Information
|Test ID||Test Order Name||Order LOINC Code|
|SBL||Blastomyces Antibody by Immunodiffusion, Serum||In Process|
|Result ID||Test Result Name||Result LOINC Code|
The dimorphic fungus, Blastomyces dermatitidis, causes blastomycosis. When the organism is inhaled, it causes pulmonary disease - cough, pain, and hemoptysis, along with fever and night sweats. It commonly spreads to the skin, bone, or internal genitalia where suppuration and granulomas are typical. Occasionally, primary cutaneous lesions after trauma are encountered; however, this type of infection is uncommon.
A positive result is suggestive of infection, but the results cannot distinguish between active disease and prior exposure.
Routine culture of clinical specimens (eg, respiratory specimen) is recommended in cases of suspected, active blastomycosis.
The Mayo experience with the immunodiffusion test is that it is positive in fewer cases of blastomycosis than the 70% to 85% reported elsewhere.
Patients with histoplasmosis may have low-titered cross reactions.
Antibodies to the mycelial and yeast forms of Blastomyces dermatitidis are detected in the patient's serum by complement fixation (CF) and immunodiffusion tests.(Kaufman L, Kovacs JA, Reiss E: Clinical immunomycology. In Manual of Clinical and Laboratory Immunology. Edited by NL Rose, E Conway-de Macario, JD Folds, et al. Washington, DC, ASM Press, 1997, pp 587-588; Kaufman L, Mclaughlin DW, Clark MJ, Blumer S: Specific immunodiffusion test for blastomycosis. Appl Microbiol 1973;26:244-247; Williams JE, Murphy R, Standard PG, Phair JP: Serologic response in blastomycosis: diagnostic value of double immunodiffusion assay. Am Rev Resp Dis 1981;123:209-212)