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HelpTest Code ADLTX Adulterants Survey, Chain of Custody, Random, Urine
Useful For
Assess the possible adulteration of a urine specimen submitted for drug of abuse testing
Providing the urine creatinine concentration for normalization purposes
Chain of custody is required whenever the results of testing could be used in a court of law. Its purpose is to protect the rights of the individual contributing the specimen by demonstrating that it was always under the control of personnel involved with testing the specimen; this control implies that the opportunity for specimen tampering would be limited.
Additional Tests
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| COCH | Chain of Custody Processing | No | Yes |
Special Instructions
Reporting Name
Adulterants Survey, CoC, USpecimen Type
UrineSpecimen Required
Supplies: Chain of Custody Kit (T282)
Container/Tube: Chain-of-custody kit containing the specimen containers, seals, and documentation required.
Specimen Volume: 1.5 mL
Collection Instructions: Collect a random specimen without preservative in the provided container, seal, and submit with the associated documentation to satisfy the legal requirements for chain-of-custody testing.
Additional Information: Submitting less than 1.5 mL will compromise the ability to perform all necessary testing.
Specimen Minimum Volume
1 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Urine | Refrigerated (preferred) | 14 days | |
| Frozen | 14 days | ||
| Ambient | 72 hours |
Reject Due To
All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.Clinical Information
Specimen adulteration is the manipulation of a sample that may cause false-negative test results for the presence of drugs of abuse. Common adulterants that may affect testing are water, soap, bleach, vinegar, oxidants, and salt. The adulteration testing includes assessment of creatinine concentration, pH, urine specific gravity, presence or absence of an oxidant, and presence or absence of nitrite.
Chain of custody is a record of the disposition of a specimen to document the individuals who collected the specimen, handled it, and performed the analysis. When a specimen is submitted in this manner, analysis will be performed in such a way that it will withstand regular court scrutiny.
Interpretation
For information see Adulterant Survey Algorithm.
Cautions
No significant cautionary statements
Method Description
All results are measured using spectrophotometry at wavelengths specified by the reagent manufacturer. The use of a refractometer may also be used in the specific gravity measurement.(Package inserts: Specimen Validity Test Creatinine. Roche Diagnostics; V3.0, 08/2015; Specimen Validity Test Nitrite. Roche Diagnostics; V3.0, 08/2018, Specimen Validity Test Oxidant. Roche Diagnostics; V 3.0, 08/2018; Specimen Validity Test pH Roche Diagnostics; V3.0, 02/2019, Specimen Validity Test Specific Gravity. Roche Diagnostics; V4.0, 08/2022)
Day(s) Performed
Monday through Saturday
Report Available
2 to 3 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Test Classification
This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| ADLTX | Adulterants Survey, CoC, U | 58715-4 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 36121 | Creatinine, U | 2161-8 |
| 36122 | Specific Gravity | 5810-7 |
| 36123 | pH | 2756-5 |
| 36124 | Oxidants | 58714-7 |
| 36125 | Nitrites | 32710-6 |
| 36126 | Comment | 48767-8 |
Method Name
Spectrophotometry
Reference Values
Cutoff concentrations
Oxidants: 200 mg/L
Nitrites: 500 mg/L
Testing Algorithm
For more information see Adulterant Survey Algorithm.