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HelpTest Code CMUMP Mumps Virus Antibodies, IgG and IgM, Spinal Fluid
Reporting Name
Mumps Virus Ab, IgG and IgM, CSFUseful For
Aiding in the diagnosis of central nervous system infection by mumps virus
Method Name
Immunofluorescence
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Specimen Type
CSFSpecimen Required
Container/Tube: Sterile vial
Specimen Volume: 0.5 mL
Collection Instructions: Submit aliquot from collection vial 1.
Specimen Minimum Volume
0.1 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| CSF | Refrigerated (preferred) | 14 days | |
| Frozen | 14 days |
Reject Due To
| Gross hemolysis | OK |
| Gross lipemia | OK |
Reference Values
IgG: <1:5
IgM: <1:10
Reference values apply to all ages.
Day(s) Performed
Monday through Friday
CPT Code Information
86735 x 2
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| CMUMP | Mumps Virus Ab, IgG and IgM, CSF | 88458-5 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 1414 | Mumps Virus Ab, IgG | 21401-5 |
| 1415 | Mumps Virus Ab, IgM | 21402-3 |
Clinical Information
There is only one serotype of mumps virus that infects humans. Mumps has been recognized since antiquity by virtue of the parotitis, which is often a striking clinical feature of the disease. Generally, a trivial childhood illness, the varied presentation of mumps reflects the widespread invasion of visceral organs and central nervous system that commonly follows infection with mumps virus.
Interpretation
Detection of organism-specific antibodies in the cerebrospinal fluid (CSF) may suggest central nervous system infection. However, these results are unable to distinguish between intrathecal antibodies and serum antibodies introduced into the CSF at the time of lumbar puncture or from a breakdown in the blood-brain barrier. The results should be interpreted with other laboratory and clinical data prior to a diagnosis of central nervous system infection.
Cautions
No significant cautionary statements
Method Description
Cerebrospinal fluid (CSF) from a patient is reacted with the antigen substrate. Antibodies, if present, will bind to the antigen forming stable antigen-antibody complexes. If no antibodies are present, the complexes will not be formed, and CSF components will be washed away. Fluorescein labeled antihuman IgG or IgM antibody is added to the reaction site which binds with the complexes formed. This results in a positive reaction of bright apple-green fluorescence when viewed with a properly equipped fluorescence microscope. If no complexes are formed, the fluorescein labeled antibody will be washed away, exhibiting a negative result.(Package insert: Mumps Virus Antigen Substrate Slide. AESKU.BION; 09/2019)