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Test Code CPAPD Conventional Smear-Diagnostic, Varies


Ordering Guidance


Laboratory approval prior to ordering cytology testing is required

 

Specimen submitted as endocervical curettage or endocervical brushing must be ordered as CYTNG/ Cytology Non-Gynecologic.



Necessary Information


1. An acceptable cytology request form must accompany specimen containers and include the following: Patient's name, medical record number, date of birth, sex, source (exact location and procedure used), date specimen was taken, name of ordering physician and pager number.

2. Submit any pertinent clinical information, including date of last menstrual period.



Specimen Required


Patient Preparation: For optimal interpretation, Papanicolaou smears should be collected near the middle of the menstrual cycle. No douching, lubricant use, or sexual intercourse for 24 hours prior to specimen collection. 

Container/Tube: Slide

Specimen Volume: Circular scrape of cervical os

Collection Instructions:

1. Specimen containers must be labeled with a minimum of 2 unique identifiers (patient's name, and medical record number or date of birth). Containers should also be labeled with specimen source, and date collected.

2. Glass slides may be labeled with a single unique identifier, but 2 identifiers are preferred. If multiple slides are submitted, each slide must have proper identification. Glass slides should be identified with the patient's name and a second patient identifier that is also on the accompanying paperwork (ie, medical record number or date of birth)

3. Fix slides immediately in 95% alcohol or treat with commercially available spray fixative.


Useful For

Screening for cervical carcinoma and a number of infections of the female genital tract including human papillomavirus, herpes, Candida, and Trichomonas

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
CVSPC Physician Interp Conventional No No

Special Instructions

Method Name

Light Microscopy

Reporting Name

Conventional Smear-Diagnostic

Specimen Type

Varies

Specimen Stability Information

Specimen Type Temperature Time Special Container
Varies Ambient (preferred) SLIDE
  Refrigerated  SLIDE

Reject Due To

SurePath vial Reject

Clinical Information

Squamous cell carcinoma of the cervix is believed to develop in progressive stages from normal through precancerous (dysplastic) stages, to carcinoma in situ, and eventually invasive carcinoma. This sequence is felt to develop over a matter of years in most patients.

 

The etiology of cervical carcinoma is unknown, but the disease is believed to be related to sexual activity and possibly sexually transmitted viral infections such as human papillomavirus (HPV).

 

Most cervical carcinomas and precancerous conditions occur in the transformation zone (squamo-columnar junction), therefore, this area needs to be sampled if optimum results are to be obtained.

Reference Values

Satisfactory for evaluation. Negative for intraepithelial lesion or malignancy.

Note: Abnormal results will be reviewed by a physician at an additional charge.

Interpretation

Standard reporting, as defined by the Bethesda System (TBS) is utilized.

Cautions

If endocervical cells have not been obtained (less than optimal smears) the results may be unreliable.

 

There is a false-negative rate of 10% to 20% in the presence of cervical intraepithelial neoplasia or invasive squamous cell carcinoma.

 

The Papanicolaou test is unreliable for endometrial carcinoma (at least 50% false-negative rate).

Method Description

Papanicolaou-stained slides are microscopically examined by a cytotechnologist. Abnormal findings are reviewed and reported by a pathologist (charged separately).(Unpublished Mayo method)

Day(s) Performed

Monday through Friday

Report Available

2 to 5 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

P3000

88164

88141-CVSPC (if appropriate)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
CPAPD Conventional Smear-Diagnostic In Process

 

Result ID Test Result Name Result LOINC Value
71306 Interpretation 59465-5
71307 Participated in the Interpretation No LOINC Needed
71308 Report electronically signed by 19139-5
71309 Addendum 35265-8
71310 Gross Description 22634-0
CY037 Pap Test Source 19763-2
CY038 Clinical History 22636-5
CY039 Menstrual Status (LMP, PM, Pregnant) 8678-5
CY040 Hormone Therapy/Contraceptives 8659-5
71573 Disclaimer 62364-5
71819 Case Number 80398-1