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HelpTest Code DSS Drug Screen, Prescription/Over the Counter, Serum
Reporting Name
Drug Screen, Prescription/OTC, SUseful For
Detection and identification of prescription or over the counter drugs frequently found in drug overdose or used with a suicidal intent
Qualitatively identifying drugs present in the specimen; quantification of identified drugs, when available, may be performed upon client request
This test is not intended for therapeutic drug monitoring or compliance testing.
This test is not intended for use in employment-related testing.
This test is not useful for drugs of abuse or illicit drug testing, including benzodiazepines, opioids, barbiturates, cocaine, amphetamine type stimulants.
Method Name
Gas Chromatography Mass Spectrometry (GC-MS)
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Specimen Type
Serum RedOrdering Guidance
This test is not performed using chain of custody. For chain-of-custody testing, order DSSX / Drug Screen, Prescription/Over the Counter, Chain of Custody, Serum.
Specimen Required
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Collection Container/Tube: Red top (serum gel/SST tubes are not acceptable)
Submission Container/Tube: Plastic vial
Specimen Volume: 2.75 mL
Collection Instructions: Within 2 hours of collection, centrifuge and aliquot serum into plastic vial.
Specimen Minimum Volume
1.1 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum Red | Refrigerated (preferred) | 14 days | |
| Frozen | 14 days | ||
| Ambient | 3 hours |
Reject Due To
| Gross hemolysis | OK |
| Gross lipemia | OK |
| Gross icterus | OK |
Special Instructions
Reference Values
Drugs detected are presumptive. Additional testing may be required to confirm the presence of any drugs detected.
Day(s) Performed
Monday through Sunday
CPT Code Information
80307
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| DSS | Drug Screen, Prescription/OTC, S | 20785-2 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 31072 | Drugs detected: | 20785-2 |
| 31168 | Chain of Custody | 77202-0 |
Clinical Information
This test looks for a broad spectrum of prescription and over-the-counter drugs. It is designed to detect drugs that have toxic effects, as well as known antidotes or active therapies that a clinician can initiate to treat the toxic effect. The test is intended to help physicians manage an apparent overdose or intoxicated patient, or to determine if a specific set of symptoms might be due to the presence of drugs. This test is not appropriate for drugs of abuse or illicit drug testing, including benzodiazepines, opioids, barbiturates, cocaine, and amphetamine type stimulants.
Drugs of toxic significance that are not detected by this test are digoxin, lithium, and many drugs of abuse or illicit drugs, some benzodiazepines, and some opioids.
For detection limits for drugs detected in this test see Prescription and Over-the-Counter Drug Screening List and Limits of Detection.
Interpretation
The drugs that are detected by this test are listed in Prescription and Over-the-Counter Drug Screening List and Limits of Detection.
The pharmacology of each drug determines how the test should be interpreted. A detailed discussion of each drug is beyond the scope of this text. If a clinical interpretation is required, contact Mayo Clinic Laboratories at 800-533-1710 and ask to speak to a toxicology consultant.
Each report will indicate the drugs detected.
Cautions
Specimens collected in serum gel tubes are not acceptable, as the drug/analyte can absorb on the gel and lead to falsely decreased concentrations.
Method Description
Screening is by gas chromatography mass spectroscopy.(Unpublished Mayo method)