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HelpTest Code HSCRP C-Reactive Protein, High Sensitivity, Serum
Reporting Name
C-Reactive Protein, High Sens, SUseful For
Assessment of risk of developing myocardial infarction in patients presenting with acute coronary syndromes
Assessment of risk of developing cardiovascular disease or ischemic events in individuals who do not manifest disease at present
Method Name
Immunoturbidimetry
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Specimen Type
SerumOrdering Guidance
This assay should be used to assess risk of cardiovascular disease or events.
To monitor or assess other inflammatory disorders, order CRP / C-Reactive Protein (CRP), Serum.
Specimen Required
Collection Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL
Collection Instructions: Centrifuge and aliquot serum into a plastic vial.
Specimen Minimum Volume
0.2 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 7 days | |
| Frozen | 30 days |
Reject Due To
| Gross hemolysis | Reject |
| Gross lipemia | Reject |
| Gross icterus | Reject |
Reference Values
≥18 years: <2.0 mg/L
Reference values have not been established for patients who are younger than 18 years.
Day(s) Performed
Monday through Saturday
CPT Code Information
86141
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| HSCRP | C-Reactive Protein, High Sens, S | 30522-7 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| HSCRP | C-Reactive Protein, High Sens, S | 30522-7 |
Clinical Information
C-reactive protein (CRP) is a biomarker of inflammation. Serum CRP concentrations increase rapidly and dramatically (100-fold or more) in response to tissue injury or inflammation. High-sensitivity CRP (hs-CRP) is more precise than standard CRP when measuring baseline (ie, normal) concentrations and enables a measure of chronic inflammation.
Atherosclerosis is an inflammatory disease and hs-CRP has been endorsed by multiple guidelines as a biomarker of atherosclerotic cardiovascular disease risk.(1-3)
A large prospective clinical trial demonstrated significantly less cardiovascular risk for patients with hs-CRP less than 2.0 mg/L.(1) More aggressive treatment strategies may be warranted in patients with hs-CRP of 2.0 mg/L or higher.
Interpretation
Values greater than 2.0 mg/L suggest an increased likelihood of developing cardiovascular disease or ischemic events.
Cautions
This test is recommended for cardiovascular risk assessment only.
C-reactive protein (CRP) is an acute-phase reactant and has high intra-individual variability. Therefore, a single test for high-sensitivity CRP (hs-CRP) may not reflect an individual patient's basal hs-CRP level. Repeat measurement may be required to firmly establish an individual's basal hs-CRP concentration. The lowest of the measurements should be used as the predictive value.
Because CRP is an acute-phase reactant, measurements in apparently healthy individuals may not truly reflect the basal level if inflammation is present.
This hs-CRP assay should be used to assess risk of cardiovascular disease or events. A different CRP test (CRP / C-Reactive Protein [CRP], Serum) should be used to monitor or assess other inflammatory disorders.
Significantly decreased CRP values may be obtained from samples taken from patients who have been treated with carboxypenicillins.(4)
No significant interference is seen from rheumatoid factors up to a concentration of 200 IU/mL.
Method Description
This is a particle-enhanced immunoturbidimetric assay. Human C-reactive protein (CRP) agglutinates with latex particles coated with monoclonal anti-CRP antibodies. The precipitate is determined turbidimetrically.(Package insert: Cardiac C-Reactive Protein (Latex) High Sensitive. Roche Diagnostics; V15.0, 04/2024)