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HelpTest Code SDLDL Small Dense Low Density Lipoprotein Cholesterol, Serum
Specimen Required
Patient Preparation: Fasting overnight (8-12 hours) required
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Collection Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL
Collection Instructions:
1. Centrifuge and aliquot serum into a plastic vial.
2. Send frozen.
Useful For
Aiding in risk management of lipoprotein disorders associated with cardiovascular disease when used in conjunction with other lipid measurements and clinical evaluation
Method Name
Enzymatic Colorimetric
Reporting Name
Small Dense LDL Cholesterol, SSpecimen Type
SerumSpecimen Minimum Volume
0.5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Frozen (preferred) | 30 days | |
| Refrigerated | 72 hours | ||
| Ambient | 8 hours |
Reject Due To
| Gross hemolysis | Reject |
| Gross lipemia | Reject |
| Gross icterus | Reject |
Clinical Information
Low-density lipoprotein cholesterol (LDL-C) has long been known to be causally associated with atherosclerotic plaque development and progression and is the main target of lowering cardiovascular disease risk. Subfractions of LDL, particularly the concentration of small dense LDL-C, have been shown to also be associated with increased risk for coronary heart disease (CHD). It is thought that the smaller particles are especially pro-atherogenic given their higher probability to transverse the arterial wall and a longer circulating half-life, likely from a lower binding affinity to the LDL receptor. Several epidemiological and pathological studies have reported an association between the concentration of small dense LDL-C and CHD. Results should be used in conjunction with the patient's medical history and other laboratory and clinical results.
Reference Values
≥18 years: <50 mg/dL
Reference values have not been established for patients who are younger than 18 years.
Interpretation
Results of 50 mg/dL or greater indicate increased risk of incident coronary heart disease (CHD) (myocardial infarction, fatal CHD, or cardiac procedure).
Cautions
Results should not be used as a replacement for low-density lipoprotein cholesterol and should not be used in risk calculators.
In very rare cases, gammopathy, in particular type IgM (Waldenstrom macroglobulinemia), may cause unreliable results.
Method Description
This test system is a multi-step method measured on automated chemistry analyzers. The assay consists of two steps and is based on the technique of using well-characterized surfactants and enzymes that selectively react with certain groups of lipoproteins.(Package insert: Small dense LDL Seiken. Roche Diagnostics; V 2.0, 11/2021)
Day(s) Performed
Monday through Friday
Report Available
1 to 3 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Test Classification
This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.CPT Code Information
83722
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| SDLDL | Small Dense LDL Cholesterol, S | 90364-1 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| SDLDL | Small Dense LDL Cholesterol, S | 90364-1 |