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HelpTest Code UHSD2 Hemosiderin, Random, Urine
Specimen Required
Container/Tube: Plastic urine container
Specimen Volume: 13 mL
Collection Instructions:
1. Collect a random urine specimen.
2. No preservative.
Useful For
Detecting hemosiderinuria, secondary to excess hemolysis, as in incompatible blood transfusions, severe acute hemolytic anemia, or hemochromatosis for external patients.
Method Name
Rous Method
Reporting Name
Hemosiderin, Random, USpecimen Type
UrineSpecimen Minimum Volume
12 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Urine | Refrigerated (preferred) | 7 days | |
| Frozen | 7 days | ||
| Ambient | 2 hours |
Reject Due To
All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.Clinical Information
When the plasma hemoglobin level is 50 to 200 mg/dL after hemolysis, the capacity of haptoglobin to bind hemoglobin is exceeded, and hemoglobin readily passes through the glomeruli of the kidney. Part of the hemoglobin is absorbed by the proximal tubular cells where the hemoglobin iron is converted to hemosiderin. When these tubular cells are later shed into the urine, hemosiderinuria results. If the hemoglobin cannot be absorbed into the tubular cells, hemoglobinuria results.
Hemosiderin is found as yellow-brown granules that are free or in epithelial cells and occasionally in casts in an acidic or neutral urine.
Reference Values
Negative
Interpretation
A positive hemosiderin indicates excess red cell destruction.
Cautions
Method Description
The Prussian blue reaction is used to demonstrate hemosiderin as first described by Rous in 1918.(Brunzel N. Microscopic examination of urine sediment. Fundamentals of Urine and Body Fluid Analysis. 4th ed. Saunders; 2018:392)
Day(s) Performed
Monday through Sunday
Report Available
1 dayPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
83070
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| UHSD2 | Hemosiderin, Random, U | 4644-1 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| HSDU2 | Hemosiderin, Random, U | 4644-1 |